Grey’s Anatomycontinues casting talented stars asSophia Bush joins the ABC medical drama in season 21,and the actress' appearance will help redeem her former show’s premature cancelation. Bush is most known for herrole as Brooke Davis inOne Tree Hill, a part she played in all nine seasons of the teen drama, from 2003 to 2012. However, Bush is also recognized for portraying Erin Lindsay inChicago PDtwo yearsafterOne Tree Hill’s ending. Following her time onChicago PD, though, Bush was cast in another series, but it didn’t experience the same success as her other projects.
Grey’s Anatomyseason 21 premiered on July 18, 2025, and ABC releases new episodes on Thursdays at 10 pm ET.
Nevertheless, Bush is still an accomplished actress, both on the small and big screen. Some ofBush’s best moviesincludeJohn Tucker Must Dieand Pixar’sIncredibles 2. Now, she is set to star in season 21 ofGrey’s Anatomy, one of the longest-running scripted primetime shows currently airing on TV, as it has over 430 episodes under its belt. Hopefully,Bush’s role inGrey’s Anatomycan make up for the unfortunate fate of her last medical drama series.
Sophia Bush Joins The Cast Of Grey’s Anatomy Season 21
Bush Plays Dr. Cass Beckman
According toDeadline,Sophia Bush has been cast to play a new character inGrey’s Anatomyseason 21 — Dr. Cass Beckman. The actress' role is being described as one of a “major recurring” nature.Bush’s first episode as Cass is scheduled for Thursday, November 7,which will be the sixth one of the season, meaning the show will evidently take a one-week break after episode 5 on October 24 due to Halloween.
Cass' character description reveals that she is ‘amiable, fun, and a little messy around the edges.’
Bush’s character, Cass, is a trauma surgeon at Seattle Presbyterian Hospital,while her husband, Dr. David Beckham is a cardiothoracic surgeon at Grey Sloan Memorial Hospital. It’s unclear how thenewGrey’s Anatomyseason 21 characterwill factor into the story, especially since she doesn’t work at Grey Sloan. However, Cass' character description reveals that she is “amiable, fun, and a little messy around the edges.” Other than that, though, nothing else is known about Bush’s role inGrey’s Anatomyseason 21.
Bush’s Return To The Medical Drama Genre Can Make Up For Good Sam’s Cancelation
CBS Canceled Good Sam After Only 1 Season
Sophia Bush’s role inGrey’s Anatomyseason 21 won’t be the first time she’s playing a doctoron TV. The actress previously starred as Dr. Sam Griffith, one of the two main characters inthe showGood Sam. CBS’s medical drama created by Katie Wech premiered in January 2022 and aired for 13 episodes on the network before its season 1 finale debuted in May. Unfortunately, the episode turned out to double as the series finale as CBS canceledGood Samshortly after season 1 concluded. So, perhaps Bush joining the cast ofGrey’s Anatomycan redeemGood Sam’s cancelation.
10 Storylines Good Sam And Grey’s Anatomy Have In Common
Sophia Bush’s new medical drama Good Sam has some similar plotlines to fan favorite TV show Grey’s Anatomy, and it’s fun to compare the two shows.
Good Samwas supposed to be the actress' grand return to network TVafterBush leftChicago PDafter season 4in 2017. It had been almost five years since Bush had held a leading role in a series, andGood Samshould have been her next big success. Instead, the medical drama epically failed and could not last past its first season. By joining the cast ofGrey’s Anatomyseason 21, though, Bush can make up forGood Sam’s shortcomings. With her new role as Dr. Cass Beckham, Bush can prove how well she can play a TV doctor.
Why Bush’s Good Sam Was Canceled
The reason forGood Sam’s cancelation was very simple — its ratings were subpar. Despite receiving decent reviews, the CBS medical drama failed to gain traction with its audience,averaging around 2.2 million viewers per episode.Not even anepisode featuring the reunion between Sophia Bush and her formerOne Tree Hillcostars, Hilarie Burton Morgan and Bethany Joy Lenz, could saveGood Sam’s poor ratings.
Davi Santos
Dr. Joey Costa
Good Samwas ultimately the lowest-rated scripted series of the season for CBS,making the decision to cancel the show quite easy. Its termination could have been seen from a mile away. However, even thoughGood Samwas a failure for Bush, it won’t stop her from taking on roles in the medical drama genre, like Dr. Cass Beckham inthe cast ofGrey’s Anatomyseason 21.
Grey’s Anatomy
Cast
Grey’s Anatomy is a medical drama series revolving around surgical interns, residents, and attendings at the fictional Grey Sloan Memorial Hospital. The show features the professional and personal lives of these medical professionals, led initially by Dr. Meredith Grey, played by Ellen Pompeo. Created by Shonda Rhimes, the series highlights the complexities of medical cases while delving into the interpersonal relationships among the hospital staff.
